How is cocaine used? National Institute on Drug Abuse (NIDA)

Users primarily administer cocaine orally, intranasally, intravenously, or by inhalation. When people snort the drug (intranasal use), they inhale cocaine powder through the nostrils, where it is absorbed into the bloodstream through the nasal tissues. Users also may rub the drug onto their gums (oral use).

What happens after taking cocaine once? Side effects and safety

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What brain states makes one person more susceptible to cocaine?

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The National Institute on Drug Abuse - NIDA - Cocaine increases levels of the natural chemical messenger dopamine in the brain. This flood of dopamine in the brain's reward circuit strongly reinforces

The National Institute on Drug Abuse - NIDA